About 50% of an oral dose may be excreted unchanged in the faeces.ĭermagran Af is an azole antifungal that functions primarily through inhibition of a specific demethylase within the CYP450 complex. Dermagran Af is inactivated in the body and 10-20% of an oral dose is excreted in the urine, mainly as metabolites, within 6 days. When administered orally, Dermagran Af is incompletely absorbed from the gastrointestinal tract, peak plasma levels of about 1 µg per ml have been achieved after a dose of 1 gm per day. It may act by interfering with the permeability of the fungal cell membranes. The active ingredient, Dermagran Af, is a synthetic imidazole anti-fungal agent with a broad spectrum of activity against pathogenic fungi (including yeast and dermatophytes) and gram-positive bacteria (Staphylococcus and Streptococcus spp).
#Dermagran dt4 skin#
Dermagran Af topical cream does not stain skin or clothes. Dermagran Af topical cream proved to be markedly effective in secondary infected mycoses, which under other treatments were resistant or reappeared. Dermagran Af Topical cream, topical gel, topical liquid, topical ointment, topical powder, topical spray, topical tinctureĭermagran Af topical cream is a broad-spectrum antimycotic which offers a high antifungal activity against dermatophytes, yeasts and other phyco-Asco and Adelomycetes, with a potent antibacterial activity against Gram-positive bacilli and cocci.
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